• Single cell omics
• Lineage tracing
• Spatial transcriptomic
• Cancer biology
• Stem cell research

Delineating the information stored within genomes and comprehending its spatial and temporal expression emerges as the primary challenge in the post-genomic era. Our group utilizes a combination of experimental and computational approaches to explore decision-making processes within individual cells, with a focus on stem cell biology and cancer evolution. We are constructing single-cell lineage tracers and pioneering novel omic techniques to capture crucial aspects of human development and cancer progression in a massively parallel manner. Through these initiatives, we aim to understand how cells utilize gene networks to make decisions in hematopoiesis and to unveil evolutionary dynamics during cancer metastasis and therapy.

Research Articles (* Co-first authors, # Co-corresponding authors):

1. Xue Y*, #, Su JH*, Chao YM*, Liu L, Lin XY, Xiang Y, Ho MK, Su ZZ, Chen JY, Luo ZJ, Lin CQ, Luo RB, Aurich T, Wu JF, Cheung KSC, Huang Y, Ho JWK#, Sugimura R# (2026) Single-cell mitochondrial lineage tracing decodes fate decision and spatial clonal architecture in human hematopoietic organoids. Advanced Science, e18084
2. Zhao Z, Gao B, Ma Y, Wang X, Jimenez N, Subirats J, Wang D, Li Q, Ho JWK, Xue Y, Wu J, Zheng L, Huang F, Yu C, Zhang J, Cai M (2025) Black soldier fly organic fertilizer restricts the mobility of soil Pseudomonas to mitigate vertical migration of antibiotic resistance genes in agricultural systems. Journal of Environmental Chemical Engineering, 13(6), 119584
3. Zhao Z, Gao B, Henawy AR, Rehman K, Ho JWK, Xue Y, Wu J, Jimenez N, Subirats J, Zheng L, Huang F, Yu C, Zhang J, Cai M (2025) Effects of chicken manure-derived black soldier fly organic fertilizer on soil carbon and nitrogen cycling: insights from metagenomic and microbial network analysis. Environmental Research, 286, Part 2, 122775.
4. Xue Y, Su ZZ, Lin XY, Ho MK, Yu KHO (2024) Single cell lineage tracing with endogenous markers. Biophysical Reviews 16, 125-139.
5. Xue Y, Yang XX, Pang L, Liu H, Liu J, Ng TPK, Yeung WHO, Lam YF, Zhang WY, Lo CM, Man K (2021) Inhibition of carnitine palmitoyltransferase 1A aggravates fatty liver graft injury via promoting mitochondrial permeability transition. Transplantation 105(3):550-560.
6. Lung SC, Liao P, Yeung EC, Hsiao AS, Xue Y, Chye ML (2018). Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors. New Phytologist 218: 183-200.
7. Chen MX, Hu TH, Xue Y, Zhu FY, Du ZY, Lo C, Chye ML (2018) Arabidopsis Acyl-Coenzyme-A-Binding Protein ACBP1 interacts with AREB1 and mediates salt and osmotic signaling in seed germination and seedling growth. Environmental and Experimental Botany 156: 130-140.
8. Lung SC, Liao P, Yeung EC, Hsiao AS, Xue Y, Chye ML (2017) Acyl-CoA-binding protein ACBP1 modulates sterol synthesis during embryogenesis. Plant Physiology,174(3):1420–1435.
9. Xue Y, Xiao S, Kim J, Lung SC, Chen L, Tanner JA, Suh MC, Chye ML (2014) Arabidopsis membrane-associated acyl-CoA-binding protein ACBP1 is involved in stem cuticle formation. Journal of Experimental Botany 65(18):5473-5483. 

Authored Books

1. Xue Y, Lung SC, Chye ML. (2016) Present status and future prospects of transgenic approaches for drought tolerance. In “Drought Tolerance in Plants, Vol 2: Molecular and Genetic Perspectives" (ISBN 978-3-319-32421-0) edited by LS Tran, DJ Burritt, MA Hossain, SH Wani and S Bhattacharjee. Springer, USA, Chapter 20, p. 549-569.

• Seed Fund (2509100304), PI.
• Seed Fund (2401103785), PI.
• Seed Fund (201811159217), Co-PI.

• China 10,000 Talents Programme, Ministry of Education, 2025
• EMBO Grant: Lineage Tracing, 2025.
• Young Investigator Award, International Liver Transplantation Society Annual Congress 2018
• Best Poster Presentation Award, Hong Kong Society for Immunology Forum 2017

• Member, International Liver Transplantation Society (ILTS)
• Member, Hong Kong Scientist Association (HKSA)